While antidepressants are routinely prescribed for the treatment of irritable bowel syndrome (IBS), a new Mayo Clinic study has found the herbal antidepressant St. John’s wort isn’t effective in treating the disorder.

Scientists conducted a placebo-controlled trial of 70 IBS patients for their results. Half of the participants received St. John’s wort and half received a placebo for a period of three months. They found that after the test period, the placebo group actually had fewer IBS symptoms including stomach pain, diarrhea, constipation and bloating than the group that received the herbal supplement.

It’s believed that as many as one out of five Americans has IBS symptoms, according to the Mayo Clinic. Among some of the alternative treatments believed to be helpful in treating the symptoms of IBS include acupuncture, hypnosis, yoga, meditation and regular exercise, as well as herbal supplements containing peppermint and taking probiotics.

St. John’s wort has been shown to be helpful in several medical conditions such as depression and other pain syndromes. Research has shown it to be as effective as conventional, prescription anti-depressants in treating mild to moderate depression.

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