Mayo Clinic researchers have found that even modest weight gains could affect blood flow and increase the risk for cardiovascular problems.

Researchers recruited 43 healthy volunteers with an average age of 29 years. They were tested for endothelial dysfunction by measuring the blood flow through their arm arteries. The volunteers were assigned to either gain weight or maintain their weight for eight weeks, and their blood flow was tested. The weight-gainers then lost the weight and were tested again.

They found that individuals who gained weight in their abdomens (known as visceral fat) had impaired blood flow through their arm arteries, even though their blood pressure remained healthy. Once the volunteers lost the weight, the blood flow recovered.

Blood flows were unchanged in those who didn’t gain weight and were less affected among those who gained weight evenly throughout their bodies.

"Endothelial dysfunction has long been associated with an increased risk for coronary artery disease and cardiovascular events," said cardiologist Virend Somers, M.D., Ph.D. "Gaining a few pounds in college, on a cruise, or over the holidays is considered harmless, but it can have cardiovascular implications, especially if the weight is gained in the abdomen."

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